Papers
I’m a scientist and group leader working at the intersection of genomics, computational biology, and target discovery.
You can find my CV on LinkedIn and a complete list of publications on Google Scholar.
Highlighted publications from the last years
2026
Human-derived cardiac-neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron
N. Gemini said Li, C. Zhang, M. Xu, Y. Choi, D. Sidarta-Oliveira, R. Dong, X. Hu, E. M. Toledo, C. A. Prada-Medina, F. Argus, K. Liu, M. Li, L. Zhou, H. Bayley, C. Smith, C. Denning, A. I. Domingos, G. Hao, D. Li, D. J. Paterson
The Journal of Physiology (2026)
Midbrain dopaminergic neurons arise from two molecularly distinct radial glia-like progenitors
Emilia Sif Asgrimsdottir, Luca Fusar Bassini, Pia Rivetti di Val Cervo, Daniel Gyllborg, Claudia Puigsallosas-Pastor, Kawai Lee, Christopher Grigsby, Saiful Islam, Peter Lonneberg, Carlos Villaescusa, Carmen Salto, Sten Linnarsson, Gioele La Manno, Enrique M Toledo, Ernest Arenas
Nature Neuroscience (2026)
Functionally Mature Bioengineered Human Skeletal Muscle Tissues Capture Essential Aspects of Glucose Metabolism
Carlos Henriquez-Olguin, Martina Kubec Højfeldt, Christopher Thomas Andrew Lewis, Jesper B. Birk, Tianfang Wang, Zelin Li, Pia Jensen, Pauline Blomquist, Bo Falck Hansen, Roberto Meneses-Valdes, Enrique Toledo, Jeb Hogan, Zhe Wang, Charis-Patricia Segeritz, Jørgen Frank Pind Wojtaszewski, Thomas Elbenhardt Jensen, Anna Blois, Christian Pehmøller, Jonas Roland Knudsen
bioRxiv (2026)
2024
Midbrain Dopaminergic Neuron Development is Regulated by Two Molecularly Distinct Subtypes of Radial Glia Cells
Emilía Sif Ásgrímsdóttir, Luca Fusar Bassini, Pia Rivetti di Val Cervo, Daniel Gyllborg, Clàudia Puigsasllosas Pastor, Kawai Lee, Christopher Grigsby, Saiful Islam, Peter Lönneberg, Carlos Villaescusa, Carmen Saltó, Sten Linnarsson, Gioele La Manno, Enrique M Toledo, Ernest Arenas
bioRxiv (2024) Now published in Nature Neuroscience
The perineurium integrates leptin with its sympathetic outflow to protect against obesity
Sarker G, Habermann E, Chandran A, Monfeuga T, Maroteau C, Lundh S, Raimondi A, Martínez Sánchez N, Arús B, Iannacone M, et al.
bioRxiv (2024)
2023
Hepatocyte mARC1 promotes fatty liver disease
Lewis LC, Chen L, Hameed LS, Kitchen RR, Maroteau C, Nagarajan SR, Norlin J, Daly CE, Szczerbinska I, Hjuler ST, et al.
JHEP Reports 5(5) (2023)
2022
TCF7L2 plays a complex role in human adipose progenitor biology, which might contribute to genetic susceptibility to type 2 diabetes
Verma M, Loh NY, Sabaratnam R, Vasan SK, van Dam AD, Todorčević M, Neville MJ, Toledo E, Karpe F, Christodoulides C, et al.
Metabolism 133 (2022)
2020
Srebf1 controls midbrain dopaminergic neurogenesis
Toledo EM, Yang S, Gyllborg D, Van Wijk KE, Sinha I, Varas-Godoy M, Grigsby CL, Lönnerberg P, Islam S, Steffensen KR, et al.
Cell Reports 31(5) (2020)
2018
A Zeb2-miR-200c loop controls midbrain dopaminergic neuron neurogenesis and migration
Yang S, Toledo EM, Rosmaninho P, Peng C, Uhlén P, Castro DS, Arenas E
Communications Biology 1(1) (2018)
2017
Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson’s disease model
Rivetti Di Val Cervo P, Romanov RA, Spigolon G, Masini D, Martín-Montañez E, Toledo EM, La Manno G, Feyder M, Pifl C, Ng YH, et al.
Nature Biotechnology 35(5) (2017)
Mapping genes for calcium signaling and their associated human genetic disorders
Hörtenhuber M, Toledo EM, Smedler E, Arenas E, Malmersjö S, Louhivuori L, Uhlén P
Bioinformatics 33(16) (2017)
Niche-derived laminin-511 promotes midbrain dopaminergic neuron survival and differentiation through YAP
Zhang D, Yang S, Toledo EM, Gyllborg D, Saltó C, Carlos Villaescusa J, Arenas E
Science Signaling 10(493) (2017)
2016
A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson’s disease
Villaescusa JC, Li B, Toledo EM, Rivetti di Val Cervo P, Yang S, Stott SRW, Kaiser K, Islam S, Gyllborg D, Laguna-Goya R, et al.
The EMBO Journal 35(18) (2016)
Molecular diversity of midbrain development in mouse, human, and stem cells
La Manno G, Gyllborg D, Codeluppi S, Nishimura K, Salto C, Zeisel A, Borm LE, Stott SRW, Toledo EM, Villaescusa JC, et al.
Cell 167(2) (2016)
2015
Anti-ribosomal P protein autoantibodies from patients with neuropsychiatric lupus impair memory in mice
Bravo-Zehnder M, Toledo EM, Segovia-Miranda F, Serrano FG, Benito MJ, Metz C, Retamal C, Alvarez A, Massardo L, Inestrosa NC, et al.
Arthritis & Rheumatology 67(1) (2015)