Papers

I’m a scientist and group leader working at the intersection of genomics, computational biology, and target discovery.

You can find my CV on LinkedIn and a complete list of publications on Google Scholar.

Highlighted publications from the last years

2026

The perineurium integrates leptin with its sympathetic outflow to protect against obesity

Gitalee Sarker, Emma Haberman, Anandhakumar Chandran, Thomas Monfeuga, Cyrielle Maroteau, Sofia Lundh, David S Oliveira, Andrea Raimondi, Karin Ziegler, Tiago Gomes, Tiago N Cordeiro, Karishma Parekh, Emilia Schmid, Paola Fernández-Sanmartín, Alina Griebel, Noelia Martinez-Sanchez, Bernardo A Arús, Samson W Cheung, Yitao Zhu, Michal Shaked, Sarah C L Knowles, Stefan Hanns Engelhardt, Matteo Iannacone, Philipp E Scherer, Miguel López, Enrique M Toledo, Ana Domingos

Nature Metabolism (2026)

Human-derived cardiac-neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

Ni Li, Chenchen Zhang, Mengying Xu, YoonYoung Choi, Davi Sidarta-Oliveira, Ruirui Dong, Xinyu Hu, Enrique M Toledo, Cesar A Prada-Medina, Finbar Argus, Kun Liu, Mingyu Li, Linna Zhou, Hagan Bayley, Corey Smith, Chris Denning, Ana I Domingos, Guoliang Hao, Dan Li, David J Paterson

The Journal of Physiology (2026)

Midbrain dopaminergic neurons arise from two molecularly distinct radial glia-like progenitors

Emilía Sif Ásgrímsdóttir, Luca Fusar Bassini, Ting Sun, Clàudia Puigsasllosas Pastor, Pia Rivetti di Val Cervo, Daniel Gyllborg, Kawai Lee, Christopher L Grigsby, Baptiste Jude, Carmen Abaurre, Saiful Islam, Peter Lönnerberg, Carlos Villaescusa, Carmen Saltó, Roger A Barker, Sten Linnarsson, Goncalo Castelo-Branco, Gioele La Manno, Enrique M Toledo, Ernest Arenas

Nature Neuroscience (2026)

Functionally Mature Bioengineered Human Skeletal Muscle Tissues Capture Essential Aspects of Glucose Metabolism

Carlos Henriquez-Olguin, Martina Kubec Højfeldt, Christopher Thomas Andrew Lewis, Jesper B. Birk, Tianfang Wang, Zelin Li, Pia Jensen, Pauline Blomquist, Bo Falck Hansen, Roberto Meneses-Valdes, Enrique Toledo, Jeb Hogan, Zhe Wang, Charis-Patricia Segeritz, Jørgen Frank Pind Wojtaszewski, Thomas Elbenhardt Jensen, Anna Blois, Christian Pehmøller, Jonas Roland Knudsen

bioRxiv (2026)

2024

Midbrain Dopaminergic Neuron Development is Regulated by Two Molecularly Distinct Subtypes of Radial Glia Cells

Emilía Sif Ásgrímsdóttir, Luca Fusar Bassini, Ting Sun, Clàudia Puigsasllosas Pastor, Pia Rivetti di Val Cervo, Daniel Gyllborg, Kawai Lee, Christopher L Grigsby, Baptiste Jude, Carmen Abaurre, Saiful Islam, Peter Lönnerberg, Carlos Villaescusa, Carmen Saltó, Roger A Barker, Sten Linnarsson, Goncalo Castelo-Branco, Gioele La Manno, Enrique M Toledo, Ernest Arenas

bioRxiv (2024) Now published in Nature Neuroscience

The perineurium integrates leptin with its sympathetic outflow to protect against obesity

Gitalee Sarker, Emma Haberman, Anandhakumar Chandran, Thomas Monfeuga, Cyrielle Maroteau, Sofia Lundh, David S Oliveira, Andrea Raimondi, Karin Ziegler, Tiago Gomes, Tiago N Cordeiro, Karishma Parekh, Emilia Schmid, Paola Fernández-Sanmartín, Alina Griebel, Noelia Martinez-Sanchez, Bernardo A Arús, Samson W Cheung, Yitao Zhu, Michal Shaked, Sarah C L Knowles, Stefan Hanns Engelhardt, Matteo Iannacone, Philipp E Scherer, Miguel López, Enrique M Toledo, Ana Domingos

bioRxiv (2024) Now published in Nature Metabolism

2023

Hepatocyte mARC1 promotes fatty liver disease

Lara C Lewis, Lingyan Chen, L Shahul Hameed, Robert R Kitchen, Cyrielle Maroteau, Shilpa R Nagarajan, Jenny Norlin, Charlotte E Daly, Iwona Szczerbinska, Sara Toftegaard Hjuler, Rahul Patel, Eilidh J Livingstone, Tom N Durrant, Elisabeth Wondimu, Soumik BasuRay, Anandhakumar Chandran, Wan-Hung Lee, Sile Hu, Barak Gilboa, Megan E Grandi, Enrique M Toledo, Abdullah H A Erikat, Leanne Hodson, William G Haynes, Natalie W Pursell, Ken Coppieters, Jan Fleckner, Joanna M M Howson, Birgitte Andersen, Maxwell A Ruby

JHEP Reports 5(5) (2023)

2022

TCF7L2 plays a complex role in human adipose progenitor biology, which might contribute to genetic susceptibility to type 2 diabetes

Manu Verma, Nellie Y Loh, Rugivan Sabaratnam, Senthil K Vasan, Andrea D van Dam, Marijana Todorčević, Matthew J Neville, Enrique Toledo, Fredrik Karpe, Constantinos Christodoulides

Metabolism 133 (2022)

2020

Srebf1 controls midbrain dopaminergic neurogenesis

Enrique M Toledo, Shanzheng Yang, Daniel Gyllborg, Kim E van Wijk, Indranil Sinha, Manuel Varas-Godoy, Christopher L Grigsby, Peter Lönnerberg, Saiful Islam, Knut R Steffensen, Sten Linnarsson, Ernest Arenas

Cell Reports 31(5) (2020)

2018

A Zeb2-miR-200c loop controls midbrain dopaminergic neuron neurogenesis and migration

Shanzheng Yang, Enrique M Toledo, Pedro Rosmaninho, Changgeng Peng, Per Uhlén, Diogo S Castro, Ernest Arenas

Communications Biology 1(1) (2018)

2017

Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson’s disease model

Pia Rivetti di Val Cervo, Roman A Romanov, Giada Spigolon, Débora Masini, Elisa Martín-Montañez, Enrique M Toledo, Gioele La Manno, Michael Feyder, Christian Pifl, Yi-Han Ng, Sara Padrell Sánchez, Sten Linnarsson, Marius Wernig, Tibor Harkany, Gilberto Fisone, Ernest Arenas

Nature Biotechnology 35(5) (2017)

Mapping genes for calcium signaling and their associated human genetic disorders

Matthias Hörtenhuber, Enrique M Toledo, Erik Smedler, Ernest Arenas, Seth Malmersjö, Lauri Louhivuori, Per Uhlén

Bioinformatics 33(16) (2017)

Niche-derived laminin-511 promotes midbrain dopaminergic neuron survival and differentiation through YAP

Dawei Zhang, Shanzheng Yang, Enrique M Toledo, Daniel Gyllborg, Carmen Saltó, J Carlos Villaescusa, Ernest Arenas

Science Signaling 10(493) (2017)

2016

A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson’s disease

J Carlos Villaescusa, Bingsi Li, Enrique M Toledo, Pia Rivetti di Val Cervo, Shanzheng Yang, Simon R W Stott, Karol Kaiser, Saiful Islam, Daniel Gyllborg, Rocio Laguna-Goya, Michael Landreh, Peter Lönnerberg, Anna Falk, Tomas Bergman, Roger A Barker, Sten Linnarsson, Licia Selleri, Ernest Arenas

The EMBO Journal 35(18) (2016)

Molecular diversity of midbrain development in mouse, human, and stem cells

Gioele La Manno, Daniel Gyllborg, Simone Codeluppi, Kaneyasu Nishimura, Carmen Saltó, Amit Zeisel, Lars E Borm, Simon R W Stott, Enrique M Toledo, J Carlos Villaescusa, Peter Lönnerberg, Jesper Ryge, Roger A Barker, Ernest Arenas, Sten Linnarsson

Cell 167(2) (2016)

2015

Anti-ribosomal P protein autoantibodies from patients with neuropsychiatric lupus impair memory in mice

Marcela Bravo-Zehnder, Enrique M Toledo, Fabián Segovia-Miranda, Felipe G Serrano, María J Benito, Claudia Metz, Claudio Retamal, Alejandra Álvarez, Loreto Massardo, Nibaldo C Inestrosa, Alfonso González

Arthritis & Rheumatology 67(1) (2015)